Dr. Pier Jr Morin, PhD, MBA

Appointments:

Assistant Professor – Biochemistry, Department of Chemistry and Biochemistry, Université de Moncton; Associate Professor – Biochemistry, Department of Biochemistry, Université de Sherbrooke                            

Affiliations:

Université de Moncton (primary)
Université de Sherbrooke (cross-appointment)

Research Interests:

Cellular signaling, kinases, brain tumours, glioblastomas

Targeting the kinome in glioblastomas

Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current therapeutic approaches are limited.  Dr. Morin and his research team focus on the identification of hyperactivated signaling pathways involved in the biogenesis and development of GBMs and which could serve as sites for targeted therapeutic intervention.  Differentially regulated protein kinases, key mediators of signal transduction and druggable targets, are characterized in primary GBM tumours and cell lines.

Membership Status:

Dr. Morin is a BHCRI Associate Member.

Phone:

(506) 858-4355

Email:

pier.morin@umoncton.ca

Address:

Rémi Rossignol building, Université de Moncton, 18 Antonine-Maillet avenue, Moncton, New Brunswick, Canada, E1A 3E9

Publications:

Courteau, L.A., Storey, K.B. et Morin, P. Jr. (2012) Differential expression of microRNA species in a freeze tolerant insect, Eurosta solidaginis. Cryobiology. In press.

Cuperlovic-Culf, M., Ferguson, D., Culf, A., Morin, P. Jr. et Touaibia, M. (2012) 1H NMR metabolomics analysis of glioblastoma subtypes: correlation between metabolomics and gene expression characteristics. J. Biol. Chem. 287: 20164-20175.

Wang, Y., Moncayo, G., Morin, P. Jr., Xue, G., Grzmil, M., Lino, M.M., Clément-Schatlo, V., Frank, S., Merlo, A et Hemmings, B.A. (2012) Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme. Oncogene. In press.

Lefort, N., Morin, P. Jr. et Cuperlovic-Culf, M. “Analysis and modeling of metabolism of cancer. In: Biomechanics of cells and tissues: experiments, models and simulations”. Springer, New York, in press, 2012.

O’Brien, P., Morin, P. Jr, Ouellette, R. et Robichaud, G.A. (2011) The Pax5 gene: A pluripotent regulator of B cell differentiation and cancer disease. Cancer Res. 71: 7345-7350.

Grzmil, M., Morin, P. Jr, Lino, M.M., Merlo, A., Frank, S., Wang, Y., Moncayo, G. et Hemmings, B.A. (2011) MAP kinase-interacting kinase 1 (MNK1) regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma. Cancer Res. 71: 2392-2402.

Morin, P. Jr et Storey, K.B. (2009) Mammalian hibernation: differential gene expression and novel application of epigenetic controls. Int. J. Dev. Biol. 53: 433-442.

Boulay, J.L., Ionescu, M.C., Sivasankaran, B., Labuhn, M., Dolder-Schlienger, B., Taylor, E., Morin, P. Jr, Hemmings, B.A., Lino, M.M., Jones, G., Maier, D. et Merlo, A. (2009) The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas. Int. J. Oncol. 35:1123-1131.

Korur, S., Huber, R.M., Sivasankaran, B., Petrich, M., Morin, P. Jr, Hemmings, B.A., Merlo, A. et Lino, M.M. (2009) GSK3beta regulates differentiation and growth arrest in glioblastoma. PLos One. 4:e7443.

Morin, P. Jr, Dubuc, A. et Storey, K.B. (2008) Differential expression of microRNA species in organs of hibernating ground squirrels: A role in translational suppression during torpor. Biochim. Biophys. Acta 1779: 628-633.